other_material
confidence high
sentiment positive
materiality 0.65
ADC Therapeutics updates with strong LOTIS-7 combo data; ZYNLONTA expansion plans detailed
ADC Therapeutics SA
- LOTIS-7 (ZYNLONTA+glofitamab) achieved 86.7% CR rate in r/r LBCL; 93.3% ORR in evaluable patients (N=30).
- LOTIS-5 Phase 3 trial fully enrolled; topline data expected 1H 2026 for potential sBLA submission.
- ZYNLONTA Phase 2 IIT in r/r MZL showed 69.2% CR and 84.6% ORR (N=26 evaluable); CR maintained in 17/18 patients.
- PSMA-targeting ADC progresses IND-enabling activities; seeking research collaborations.
- Cash runway expected into 2028; company continues to grow ZYNLONTA revenue.
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