{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-23-000228","form_type":"8-K","ticker":"LENZ","cik":"0001815776","company_name":"LENZ Therapeutics, Inc.","filed_at":"2023-01-05T23:59:59+00:00","discovered_at":"2026-05-14T18:03:46.720007+00:00","generated_at":"2026-06-20T19:46:36.109655+00:00","sec_items":["8.01","9.01"],"event_type":"regulatory","sentiment":"negative","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Graphite Bio pauses Phase 1/2 sickle cell gene therapy study after serious adverse event in first patient","bullets":["First patient dosed with nula-cel experienced prolonged pancytopenia requiring ongoing transfusion and growth factor support.","Company will not meet guidance for initial proof-of-concept data in mid-2023; IND for GPH102 in beta-thalassemia delayed beyond mid-2024.","Company working to identify operational efficiencies to extend cash runway to at least 2026; will provide business update by end of Q1 2023.","Patient achieved neutrophil engraftment with no evidence of myelodysplasia; event reported to FDA."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-23-000228","json":"https://secwatch.observer/filing/0000950170-23-000228.json","markdown":"https://secwatch.observer/filing/0000950170-23-000228.md","text":"https://secwatch.observer/filing/0000950170-23-000228.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1815776/000095017023000228/0000950170-23-000228-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1815776/000095017023000228/grph-20230105.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-20T19:46:36.109655+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}