other material
confidence high
sentiment positive
materiality 0.55
SAB Biotherapeutics completes GLP-tox study for SAB-142 T1D therapeutic; IND filing within 12 months
SAB Biotherapeutics, Inc.
- SAB-142 well tolerated in GLP-tox study; dose-dependent pharmacologic effect confirmed.
- First fully-human anti-thymocyte hpAB for type 1 diabetes; may avoid immune reactions seen with animal-derived antibodies.
- SAB to submit IND filing within approximately 12 months.
- SAB-142 dosed at 1, 5, and 10 mg/kg; prolonged lymphodepletion suggests potential for optimized dosing.
- Potential to delay onset/progression of type 1 diabetes and other T-cell mediated autoimmune diseases.