---
schema_version: "secwatch.filing_event.v1"
accession: "0000950170-23-005091"
form_type: "8-K"
ticker: "ALEC"
cik: "0001653087"
company_name: "Alector, Inc."
filed_at: "2023-02-28T23:59:59+00:00"
generated_at: "2026-06-18T22:16:59.963380+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Alector reports Q4 2022 net loss of $52.4M; cash runway through 2025

## Summary
- Net loss Q4 2022: $52.4M ($0.63/share) vs $55.6M ($0.68) in Q4 2021; full-year net loss $133.3M ($1.62) vs $36.3M ($0.45).
- Cash, cash equivalents, investments $712.9M as of Dec 31, 2022; management expects runway through 2025.
- 2023 guidance: collaboration revenue $15-25M, R&D expenses $225-245M, G&A expenses $60-70M.
- INVOKE-2 Phase 2 enrollment completion expected Q3 2023, data by Q4 2024; $17.8M milestone from AbbVie triggered.
- INFRONT-3 pivotal trial for latozinemab: regulatory engagement mid-2023, data readout early 2025.

## SEC filing metadata
- accession: 0000950170-23-005091
- form_type: 8-K
- ticker: ALEC
- cik: 0001653087
- company_name: Alector, Inc.
- filed_at: 2023-02-28T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1653087/000095017023005091/0000950170-23-005091-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1653087/000095017023005091/alec-20230228.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0000950170-23-005091
- JSON: https://secwatch.observer/filing/0000950170-23-005091.json
- Plain text: https://secwatch.observer/filing/0000950170-23-005091.txt

## Key facts
- Earnings Releases
  Alector, Inc. reported financial results for the quarter ended December 31, 2022.
  - Period: the quarter ended December 31, 2022
  - Result: reported results
  source text: On February 28, 2023, Alector, Inc. (the “Company”) announced its financial results for the quarter ended December 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1653087/000095017023005091/0000950170-23-005091-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.