---
schema_version: "secwatch.filing_event.v1"
accession: "0000950170-23-006240"
form_type: "8-K"
ticker: "ANNX"
cik: "0001528115"
company_name: "Annexon, Inc."
filed_at: "2023-03-06T23:59:59+00:00"
generated_at: "2026-06-18T11:29:13.828891+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.6
calibrated_materiality_score: 0.6
confidence: "high"
source: SEC EDGAR
---

# Annexon reports Q4 2022 net loss of $34.4M; cash runway into 2025; reiterates pipeline milestones

## Summary
- Net loss of $34.4M for Q4 2022 ($141.9M full year) vs $37.4M Q4 2021.
- Cash and equivalents $242.7M as of Dec 31, 2022; expected to fund operations into 2025.
- R&D expenses $28.5M in Q4 2022 ($112.5M full year) vs $27.2M Q4 2021.
- Phase 2 trial of ANX007 in geographic atrophy on track for initial data mid-2023.
- Phase 1 MAD trial of ANX1502 initiated; proof-of-concept in CAD planned for 2023.

## SEC filing metadata
- accession: 0000950170-23-006240
- form_type: 8-K
- ticker: ANNX
- cik: 0001528115
- company_name: Annexon, Inc.
- filed_at: 2023-03-06T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.6
- calibrated_materiality_score: 0.6
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1528115/000095017023006240/0000950170-23-006240-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1528115/000095017023006240/annx-20230306.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0000950170-23-006240
- JSON: https://secwatch.observer/filing/0000950170-23-006240.json
- Plain text: https://secwatch.observer/filing/0000950170-23-006240.txt

## Key facts
- Earnings Releases
  Annexon, Inc. reported fourth quarter and the year ended December 31, 2022 results: net income Net loss was $34.4 million for the quarter ended December 31, 2022, and $141.9 million for the year ended December 31, 2.
  - Period: fourth quarter and the year ended December 31, 2022
  - Net income: Net loss was $34.4 million for the quarter ended December 31, 2022, and $141.9 million for the year ended December 31, 2
  - Result: reported results
  source text: On March 6, 2023, Annexon, Inc. (the “Company”) announced certain financial results for the fourth quarter and the year ended December 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1528115/000095017023006240/0000950170-23-006240-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.