{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-23-010430","form_type":"8-K","ticker":"SYBX","cik":"0001527599","company_name":"SYNLOGIC, INC.","filed_at":"2023-03-29T23:59:59+00:00","discovered_at":"2026-05-14T18:03:45.394282+00:00","generated_at":"2026-06-17T10:19:59.736200+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"neutral","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Synlogic reports Q4 2022 net loss $16.7M; PKU Phase 3 on track for H1 2023","bullets":["Q4 2022 net loss $16.7M ($0.24/share) vs $15.1M ($0.21) in Q4 2021; full year net loss $66.1M ($0.92/share).","Cash, cash equivalents and marketable securities $77.6M; projected runway into H2 2024.","PKU program SYNB1934 on track for Phase 3 trial initiation in H1 2023; Rare Pediatric Disease Designation granted.","SYNB1353 for HCU received Rare Pediatric Disease Designation; proof of mechanism in Phase 1 study."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-23-010430","json":"https://secwatch.observer/filing/0000950170-23-010430.json","markdown":"https://secwatch.observer/filing/0000950170-23-010430.md","text":"https://secwatch.observer/filing/0000950170-23-010430.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/0000950170-23-010430-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/sybx-20230329.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-17T10:19:59.736200+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[{"claim_id":"9a9af56f975b8d60981719b3108b09c1a5925d05","claim":"SYNLOGIC, INC. reported financial results for the quarter and full year ended December 31, 2022.","evidence_excerpt":"On March 29, 2023, Synlogic, Inc. (the “Company”) announced its financial results for the quarter and full year ended December 31, 2022.","evidence_source":"SEC 8-K Item 2.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/0000950170-23-010430-index.htm","confidence":1.0,"family_label":"Earnings Releases","details":[{"label":"Period","value":"the quarter and full year ended December 31, 2022"},{"label":"Result","value":"reported results"}],"fact_type":"earnings_release"}],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}