---
schema_version: "secwatch.filing_event.v1"
accession: "0000950170-23-010430"
form_type: "8-K"
ticker: "SYBX"
cik: "0001527599"
company_name: "SYNLOGIC, INC."
filed_at: "2023-03-29T23:59:59+00:00"
generated_at: "2026-06-17T10:19:59.736200+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Synlogic reports Q4 2022 net loss $16.7M; PKU Phase 3 on track for H1 2023

## Summary
- Q4 2022 net loss $16.7M ($0.24/share) vs $15.1M ($0.21) in Q4 2021; full year net loss $66.1M ($0.92/share).
- Cash, cash equivalents and marketable securities $77.6M; projected runway into H2 2024.
- PKU program SYNB1934 on track for Phase 3 trial initiation in H1 2023; Rare Pediatric Disease Designation granted.
- SYNB1353 for HCU received Rare Pediatric Disease Designation; proof of mechanism in Phase 1 study.

## SEC filing metadata
- accession: 0000950170-23-010430
- form_type: 8-K
- ticker: SYBX
- cik: 0001527599
- company_name: SYNLOGIC, INC.
- filed_at: 2023-03-29T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/0000950170-23-010430-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/sybx-20230329.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0000950170-23-010430
- JSON: https://secwatch.observer/filing/0000950170-23-010430.json
- Plain text: https://secwatch.observer/filing/0000950170-23-010430.txt

## Key facts
- Earnings Releases
  SYNLOGIC, INC. reported financial results for the quarter and full year ended December 31, 2022.
  - Period: the quarter and full year ended December 31, 2022
  - Result: reported results
  source text: On March 29, 2023, Synlogic, Inc. (the “Company”) announced its financial results for the quarter and full year ended December 31, 2022.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1527599/000095017023010430/0000950170-23-010430-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.