other material
confidence high
sentiment positive
materiality 0.75
Bolt Biotherapeutics reports positive BDC-1001 Phase 1 data; advances to Phase 2; cash $192.8M
Bolt Biotherapeutics, Inc.
- BDC-1001 elicited objective responses including partial responses and stable disease across multiple HER2+ solid tumors as monotherapy and with nivolumab.
- Phase 2 program to start in 2023: two studies in breast, colorectal, endometrial, and gastroesophageal cancers.
- Entered clinical supply agreement with Roche for pertuzumab (Perjeta) to combine with BDC-1001 in breast cancer.
- Cash, cash equivalents, and marketable securities of $192.8M as of Dec 31, 2022, expected to fund operations through 2025.
- Full-year 2022 collaboration revenue $5.7M; R&D expenses $73.1M; loss from operations $90.3M.