{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-23-047585","form_type":"8-K","ticker":"DTIL","cik":"0001357874","company_name":"PRECISION BIOSCIENCES INC","filed_at":"2023-09-12T23:59:59+00:00","discovered_at":"2026-05-14T18:03:33.695313+00:00","generated_at":"2026-06-10T20:40:09.369407+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Precision BioSciences unveils mitoARCUS program PBGENE-PMM; HBV program on track for 2024 filing","bullets":["Announced PBGENE-PMM, first mitoARCUS candidate targeting m.3243 primary mitochondrial myopathy; CTA/IND submission targeted for 2025.","Lead PBGENE-HBV for chronic hepatitis B on track for CTA/IND in 2024; data shows potential to eliminate cccDNA and integrated HBV DNA.","PBGENE-NVS with Novartis aims for in vivo transgene insertion for sickle cell and beta thalassemia; PBGENE-DMD with Lilly subsidiary excises ~500k base pair dystrophin hot spot.","Partner iECURE-OTC for OTC deficiency showed >20% gene insertion efficiency at 12 months; CTA/IND submission targeted for 2023.","Company highlights ARCUS platform advantages: unique cut, size, simplicity enabling viral/mitochondrial genome elimination, gene excision, and insertion."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-23-047585","json":"https://secwatch.observer/filing/0000950170-23-047585.json","markdown":"https://secwatch.observer/filing/0000950170-23-047585.md","text":"https://secwatch.observer/filing/0000950170-23-047585.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1357874/000095017023047585/0000950170-23-047585-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1357874/000095017023047585/dtil-20230912.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-10T20:40:09.369407+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}