other material
confidence high
sentiment negative
materiality 0.85
Xenon partner Neurocrine's Phase 2 trial of NBI-921352 in focal seizures fails
Xenon Pharmaceuticals Inc.
- Phase 2 study of NBI-921352 in adult focal onset seizures failed to show meaningful seizure reduction.
- Neurocrine will not pursue further development of NBI-921352 in focal onset seizures.
- Xenon to review data for potential implications on ongoing SCN8A-developmental epileptic encephalopathy study.
- Neurocrine continues pre-clinical development of dual selective Nav1.2/1.6 inhibitor under collaboration.