{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-013803","form_type":"8-K","ticker":"SYBX","cik":"0001527599","company_name":"SYNLOGIC, INC.","filed_at":"2024-02-12T23:59:59+00:00","discovered_at":"2026-05-14T18:03:24.498375+00:00","generated_at":"2026-06-06T04:16:46.174412+00:00","sec_items":["2.02","2.05","5.02","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":1.0,"calibrated_materiality_score":1.0,"confidence":"high","headline":"Synlogic discontinues PKU study after data review; to cease operations, cut ~90% workforce, evaluate strategic options","bullets":["Synpheny-3 study of SYNB1934 for PKU discontinued; internal data review found it unlikely to meet primary endpoint; safety acceptable.","Company will cease operations and explore strategic alternatives including acquisition, merger, reverse merger, sale of assets, or dissolution.","Workforce reduced by ~90%; CEO Aoife Brennan to depart March 9, 2024; estimated $6M in severance costs.","Cash, equivalents, and short-term investments at Dec 31, 2023: $47.7M (unaudited)."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-013803","json":"https://secwatch.observer/filing/0000950170-24-013803.json","markdown":"https://secwatch.observer/filing/0000950170-24-013803.md","text":"https://secwatch.observer/filing/0000950170-24-013803.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1527599/000095017024013803/0000950170-24-013803-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1527599/000095017024013803/sybx-20240212.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-06T04:16:46.174412+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[{"claim_id":"7e5e59cce8","claim":"Aoife Brennan resigned as Director at SYNLOGIC, INC..","evidence_excerpt":"Dr. Brennan also resigned from the Company’s Board of Directors, effective March 9, 2024.","evidence_source":"SEC 8-K Item 5.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1527599/000095017024013803/0000950170-24-013803-index.htm","confidence":0.95,"family_label":"Executive change","details":[{"label":"Action","value":"resigned"},{"label":"Role","value":"Director"}],"fact_type":"executive_change"},{"claim_id":"d9c856d8d3","claim":"Aoife Brennan was terminated as President and Chief Executive Officer at SYNLOGIC, INC..","evidence_excerpt":"the Company and Aoife Brennan, M.B. Ch.B., the Company’s President and Chief Executive Officer, agreed on February 8, 2024 that Dr. Brennan’s employment with the Company will terminate effective as of March 9, 2024.","evidence_source":"SEC 8-K Item 5.02","evidence_url":"https://www.sec.gov/Archives/edgar/data/1527599/000095017024013803/0000950170-24-013803-index.htm","confidence":0.95,"family_label":"Executive change","details":[{"label":"Action","value":"terminated"},{"label":"Role","value":"President and Chief Executive Officer"}],"fact_type":"executive_change"},{"claim_id":"f1954be4e3ccfbd12952d9bf0befcabae790e41a","claim":"SYNLOGIC, INC. announced a restructuring with charges of approximately $6 million affecting corporate (approximately 90%).","evidence_excerpt":"On February 8, 2024, the Company announced that it is implementing a reduction in workforce by approximately 90%. The decision was based on cost-reduction initiatives intended to reduce the Company’s ongoing operating expenses and maximize shareholder value as the Company plans to pursue strategic options. The Company expects to complete substantially all of the reduction in workforce by the end of the fiscal quarter ending March 31, 2024. The Company estimates that it will incur approximately $6 million of costs in connection with the reduction in workforce related to severance pay and other related termination benefits.","evidence_source":"SEC 8-K Item 2.05/2.06","evidence_url":"https://www.sec.gov/Archives/edgar/data/1527599/000095017024013803/0000950170-24-013803-index.htm","confidence":0.9,"family_label":"Restructurings & Charges","details":[{"label":"Type","value":"restructuring"},{"label":"Charge","value":"approximately $6 million"},{"label":"Affected area","value":"corporate"},{"label":"Headcount","value":"approximately 90%"}],"fact_type":"restructuring_charge"}],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}