{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-021425","form_type":"8-K","ticker":"JANX","cik":"0001817713","company_name":"Janux Therapeutics, Inc.","filed_at":"2024-02-27T23:59:59+00:00","discovered_at":"2026-05-14T18:03:25.662265+00:00","generated_at":"2026-06-05T12:34:33.153331+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Janux reports positive interim Phase 1a data for PSMA-TRACTr and EGFR-TRACTr; cash at $338.2M","bullets":["At JANX007 starting dose ≥0.2 mg, 6/6 (100%) achieved PSA30 and 5/6 (83%) PSA50; one PSA90 observed.","CRS for JANX007 only Grade 1/2 and transient; doses up to 3 mg with no MTD reached.","JANX008: One NSCLC subject with confirmed PR (100% lung target reduction, liver mets eliminated); no CRS or TRAEs.","11 heavily pre-treated subjects enrolled across four tumor types in JANX008; no SAEs or DLTs.","Preliminary cash, equivalents, and short-term investments ~$338.2M as of Jan 31, 2024 (incl. $0.8M restricted)."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-021425","json":"https://secwatch.observer/filing/0000950170-24-021425.json","markdown":"https://secwatch.observer/filing/0000950170-24-021425.md","text":"https://secwatch.observer/filing/0000950170-24-021425.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1817713/000095017024021425/0000950170-24-021425-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1817713/000095017024021425/janx-20240227.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-05T12:34:33.153331+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}