{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-055046","form_type":"8-K","ticker":"CYTK","cik":"0001061983","company_name":"CYTOKINETICS INC","filed_at":"2024-05-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:17.130039+00:00","generated_at":"2026-06-02T08:34:26.576830+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"Cytokinetics reports positive Phase 1 data for CK-586; Phase 2 in HFpEF expected Q4 2024","bullets":["Phase 1 study of CK-586 met primary safety, tolerability, PK objectives; no serious adverse events observed.","CK-586 is a novel cardiac myosin inhibitor for heart failure with preserved ejection fraction (HFpEF).","Phase 2 trial in HFpEF patients expected to begin in Q4 2024; based on Phase 1 safety and PK profile.","Echocardiography showed pharmacodynamics consistent with expectations; linear PK across doses 10-600 mg.","Aficamten, company's other cardiac myosin inhibitor, supported mechanism in non-obstructive HCM."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-055046","json":"https://secwatch.observer/filing/0000950170-24-055046.json","markdown":"https://secwatch.observer/filing/0000950170-24-055046.md","text":"https://secwatch.observer/filing/0000950170-24-055046.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1061983/000095017024055046/0000950170-24-055046-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1061983/000095017024055046/cytk-20240508.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-02T08:34:26.576830+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}