8-K
filed May 13, 2024, 7:59 PM ET
ticker CYTK
CIK 0001061983
other material
confidence high
sentiment positive
materiality 0.85
Aficamten Phase 3 SEQUOIA-HCM meets primary endpoint: pVO2 improved 1.8 vs 0.0 mL/kg/min (p=0.000002)
CYTOKINETICS INC
- All 10 prespecified secondary endpoints met, including KCCQ-CSS (+7 points, p<0.0001) and NYHA class improvement (34%, p<0.0001).
- Treatment reduced days eligible for septal reduction therapy by 78 days vs placebo (p<0.0001).
- No treatment interruptions due to low LVEF; serious adverse events 5.6% aficamten vs 9.3% placebo.
- Results presented at ESC Heart Failure 2024 and published in New England Journal of Medicine.
- Composite responder endpoint achieved by 42% aficamten vs 14% placebo (p<0.0001).
Machine-readable event card
- schema_version
- secwatch.filing_event.v1
- accession
- 0000950170-24-058654
- form_type
- 8-K
- ticker
- CYTK
- cik
- 0001061983
- company_name
- CYTOKINETICS INC
- filed_at
- 2024-05-13T23:59:59+00:00
- discovered_at
- 2026-05-14T18:03:17.131095+00:00
- generated_at
- 2026-06-02T01:50:08.603813+00:00
- sec_items
- ["8.01", "9.01"]
- event_type
- other_material
- sentiment
- positive
- materiality_score
- 0.85
- calibrated_materiality_score
- 0.85
- confidence
- high
- secwatch_canonical_url
- https://secwatch.observer/filing/0000950170-24-058654
- json_url
- https://secwatch.observer/filing/0000950170-24-058654.json
- markdown_url
- https://secwatch.observer/filing/0000950170-24-058654.md
- text_url
- https://secwatch.observer/filing/0000950170-24-058654.txt
- edgar_index_url
- https://www.sec.gov/Archives/edgar/data/1061983/000095017024058654/0000950170-24-058654-index.htm
- edgar_primary_document_url
- https://www.sec.gov/Archives/edgar/data/1061983/000095017024058654/cytk-20240513.htm
- generated_by_model
- deepseek-v4-flash:cloud@v2
- review_status
- machine_generated
- human_reviewed
- false
- corrected
- false
- correction_note
- null
- correction_timestamp
- null
- superseded_by
- null
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