{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-078159","form_type":"8-K","ticker":"GLUE","cik":"0001826457","company_name":"Monte Rosa Therapeutics, Inc.","filed_at":"2024-06-27T23:59:59+00:00","discovered_at":"2026-05-14T18:03:20.444485+00:00","generated_at":"2026-06-01T01:07:22.018732+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.8,"calibrated_materiality_score":0.8,"confidence":"high","headline":"Monte Rosa: MRT-2359 dose update; MRT-6160 IND for autoimmune diseases","bullets":["MRT-2359 Phase 1/2: favorable safety at 0.5 mg 21/7 schedule; evaluating 0.75 mg cohort; RP2D and updated data expected H2 2024.","IND submitted for MRT-6160, VAV1-directed MGD for systemic/neurological autoimmune diseases; Phase 1 SAD/MAD starts summer 2024 with data Q1 2025.","MRT-2359 potential RP2D of 0.5 mg using 21 days on/7 days off regimen, allowing twice as frequent dosing per cycle vs prior schedule.","MRT-6160 is first rationally designed MGD for non-oncology indication; preclinical efficacy in IBD, RA, MS models."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-078159","json":"https://secwatch.observer/filing/0000950170-24-078159.json","markdown":"https://secwatch.observer/filing/0000950170-24-078159.md","text":"https://secwatch.observer/filing/0000950170-24-078159.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1826457/000095017024078159/0000950170-24-078159-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1826457/000095017024078159/glue-20240627.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T01:07:22.018732+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}