{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-106614","form_type":"8-K","ticker":"APVO","cik":"0001671584","company_name":"Aptevo Therapeutics Inc.","filed_at":"2024-09-16T23:59:59+00:00","discovered_at":"2026-05-14T18:03:14.045043+00:00","generated_at":"2026-05-31T04:37:21.529531+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Aptevo/Alligator Phase 1 ALG.APV-527 trial: 60% stable disease, 11+ month duration in breast cancer","bullets":["Phase 1 data presented at ESMO: 9 of 15 evaluable patients (60%) achieved stable disease across solid tumors.","Breast cancer patient with progressive disease at entry achieved SD for >11 months and dose-escalated twice.","Colon cancer patient with sustained SD remains on study for over 4 months.","No maximum tolerated dose identified; safety profile positive across all cohorts.","Serum concentrations consistent with dose and preclinical predictions; biomarker analyses confirm biological activity."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-106614","json":"https://secwatch.observer/filing/0000950170-24-106614.json","markdown":"https://secwatch.observer/filing/0000950170-24-106614.md","text":"https://secwatch.observer/filing/0000950170-24-106614.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1671584/000095017024106614/0000950170-24-106614-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1671584/000095017024106614/apvo-20240916.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T04:37:21.529531+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}