{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-120268","form_type":"8-K","ticker":"ATOS","cik":"0001488039","company_name":"ATOSSA THERAPEUTICS, INC.","filed_at":"2024-11-04T23:59:59+00:00","discovered_at":"2026-05-14T18:03:08.567804+00:00","generated_at":"2026-05-30T05:59:11.061172+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Atossa reports positive Phase 2 data for (Z)-endoxifen reducing breast density by up to 26.5%","bullets":["Relative MBD reduction of 19.3% (1 mg) and 26.5% (2 mg) vs placebo in KARISMA-Endoxifen trial.","Mean plasma endoxifen: 5.18 ng/mL (1 mg) and 10.87 ng/mL (2 mg) after 1 month; stable at 3 and 6 months.","Drug-related discontinuations: 4 placebo, 5 (1 mg), 12 (2 mg); vasomotor symptoms minimal on 10-point scale.","Historical tamoxifen study: 10%+ density reduction associates with 62% lower 5-year breast cancer incidence.","Detailed results to be presented at San Antonio Breast Cancer Symposium in December 2024."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-120268","json":"https://secwatch.observer/filing/0000950170-24-120268.json","markdown":"https://secwatch.observer/filing/0000950170-24-120268.md","text":"https://secwatch.observer/filing/0000950170-24-120268.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1488039/000095017024120268/0000950170-24-120268-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1488039/000095017024120268/atos-20241104.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-30T05:59:11.061172+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}