{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-24-129971","form_type":"8-K","ticker":"APVO","cik":"0001671584","company_name":"Aptevo Therapeutics Inc.","filed_at":"2024-11-22T23:59:59+00:00","discovered_at":"2026-05-14T18:03:09.177174+00:00","generated_at":"2026-05-29T19:47:16.823559+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.3,"calibrated_materiality_score":0.3,"confidence":"medium","headline":"Aptevo highlights bispecific pipeline; first AML patient shows 90% blast reduction","bullets":["First patient in Phase 1b/2 RAINIER trial for mipletamig achieved 90% leukemic blast reduction within 30 days.","ALG.APV-527 Phase 1 data: 9 of 16 evaluable patients (56%) achieved stable disease; safety and tolerability positive.","Preclinical candidates APVO711, APVO603, APVO442 target PD-L1/CD40, 4-1BB/OX40, PSMA/CD3 respectively.","Company plans to add another targeted asset to pipeline in near-term but provides no details.","No financial updates or guidance provided; no leadership or corporate changes."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-24-129971","json":"https://secwatch.observer/filing/0000950170-24-129971.json","markdown":"https://secwatch.observer/filing/0000950170-24-129971.md","text":"https://secwatch.observer/filing/0000950170-24-129971.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1671584/000095017024129971/0000950170-24-129971-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1671584/000095017024129971/apvo-20241122.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-29T19:47:16.823559+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}