secwatch / observer

8-K filed December 3, 2024, 6:59 PM ET ticker TERN CIK 0001831363

other material confidence high sentiment positive materiality 0.85

Terns reports positive Phase 1 CARDINAL data for TERN-701 in CML; MMR rate 50% at 3 months

Terns Pharmaceuticals, Inc.

15 patients enrolled across 160mg, 320mg, 400mg QD; 14 of 15 remain on treatment as of Oct 28, 2024 cutoff.
Cumulative MMR rate 50% (5/10) in non-T315i patients with ≥3 months treatment or MMR at baseline.
No dose-limiting toxicities, AE-related discontinuations, dose reductions, or Grade 3+ treatment-related AEs.
At 160mg and 320mg, free drug concentrations 4- and 8-fold above efficacious in vivo exposures.
Dose expansion to start 1H25; longer-term MMR data expected in 4Q25.

item 7.01 item 8.01 item 9.01

Machine-readable event card

schema_version: secwatch.filing_event.v1
accession: 0000950170-24-132452
form_type: 8-K
ticker: TERN
cik: 0001831363
company_name: Terns Pharmaceuticals, Inc.
filed_at: 2024-12-03T23:59:59+00:00
discovered_at: 2026-05-14T18:03:09.902109+00:00
generated_at: 2026-05-29T09:59:39.672137+00:00
sec_items: ["7.01", "8.01", "9.01"]
event_type: other_material
sentiment: positive
materiality_score: 0.85
calibrated_materiality_score: 0.85
confidence: high
secwatch_canonical_url: https://secwatch.observer/filing/0000950170-24-132452
json_url: https://secwatch.observer/filing/0000950170-24-132452.json
markdown_url: https://secwatch.observer/filing/0000950170-24-132452.md
text_url: https://secwatch.observer/filing/0000950170-24-132452.txt
edgar_index_url: https://www.sec.gov/Archives/edgar/data/1831363/000095017024132452/0000950170-24-132452-index.htm
edgar_primary_document_url: https://www.sec.gov/Archives/edgar/data/1831363/000095017024132452/tern-20241203.htm
generated_by_model: deepseek-v4-flash:cloud@v2
review_status: machine_generated
human_reviewed: false
corrected: false
correction_note: null
correction_timestamp: null
superseded_by: null

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