{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-25-020424","form_type":"8-K","ticker":"CRBP","cik":"0001595097","company_name":"Corbus Pharmaceuticals Holdings, Inc.","filed_at":"2025-02-14T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.111499+00:00","generated_at":"2026-05-26T21:21:36.940217+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Corbus CRB-701 Phase 1 Western data: low neuropathy, HNSCC responses, dose optimization started","bullets":["No DLTs; peripheral neuropathy 5% (Grade 1-2) vs 3% in China; combined 4% across 75 patients.","Ocular AEs lower in Western study (38% vs 66%) with proactive prevention protocol at 2.7/3.6 mg/kg.","Efficacy: 4 PR in HNSCC (n=7); 1 CR in cervical; mUC responses despite prior EV treatment.","PK comparable to China; CRB-701 shows longer ADC half-life and lower free-MMAE vs enfortumab vedotin.","Dose optimization randomized at 2.7 and 3.6 mg/kg Q3W in HNSCC, cervical, and mUC cohorts."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-25-020424","json":"https://secwatch.observer/filing/0000950170-25-020424.json","markdown":"https://secwatch.observer/filing/0000950170-25-020424.md","text":"https://secwatch.observer/filing/0000950170-25-020424.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1595097/000095017025020424/0000950170-25-020424-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1595097/000095017025020424/crbp-20250214.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-26T21:21:36.940217+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}