{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-25-036306","form_type":"8-K","ticker":"OKUR","cik":"0001637715","company_name":"OnKure Therapeutics, Inc.","filed_at":"2025-03-10T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.266785+00:00","generated_at":"2026-05-25T01:34:37.945947+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"neutral","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"OnKure Q4 2024 net loss $17.4M; cash $110.8M; PIKture-01 data in H2 2025","bullets":["Net loss Q4 2024 $17.4M ($1.37/share) vs $9.5M ($30.14/share) in Q4 2023; R&D expense rose $5.6M.","Cash and equivalents $110.8M; expected to fund operations into Q4 2026 through multiple clinical readouts.","PIKture-01 Part A monotherapy enrollment near complete; PK and preliminary efficacy data expected H2 2025.","Part B fulvestrant combination dosing initiated through 900 mg BID cohort; initial data due H2 2025.","Pan-mutant PI3Kα development candidate to be announced in Q2 2025; aims for ~10x selectivity over wild type."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-25-036306","json":"https://secwatch.observer/filing/0000950170-25-036306.json","markdown":"https://secwatch.observer/filing/0000950170-25-036306.md","text":"https://secwatch.observer/filing/0000950170-25-036306.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1637715/000095017025036306/0000950170-25-036306-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1637715/000095017025036306/okur-20250310.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-25T01:34:37.945947+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}