{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-25-044783","form_type":"8-K","ticker":"MREO","cik":"0001719714","company_name":"Mereo BioPharma Group plc","filed_at":"2025-03-26T23:59:59+00:00","discovered_at":"2026-05-14T18:03:04.579262+00:00","generated_at":"2026-05-24T05:02:24.695309+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"neutral","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Mereo BioPharma FY2024 net loss $43.3M; cash $69.8M funds operations into 2027","bullets":["Net loss of $43.3M in FY2024 vs $29.5M in FY2023; R&D expenses rose $3.5M to $20.9M driven by alvelestat and setrusumab.","Cash and equivalents of $69.8M as of Dec 31, 2024; expected to fund operations into 2027.","Phase 3 Orbit study of setrusumab in OI progressing; second interim analysis expected mid-2025, final Q4 2025.","Alvelestat granted EU Orphan Designation for AATD-LD in Q1 2025; partnering discussions ongoing.","Pre-commercial activities for setrusumab in Europe advancing with NICE and GBA scientific advice."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-25-044783","json":"https://secwatch.observer/filing/0000950170-25-044783.json","markdown":"https://secwatch.observer/filing/0000950170-25-044783.md","text":"https://secwatch.observer/filing/0000950170-25-044783.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1719714/000095017025044783/0000950170-25-044783-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1719714/000095017025044783/mreo-20250326.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-24T05:02:24.695309+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}