{"schema_version":"secwatch.filing_event.v1","accession":"0000950170-25-070906","form_type":"8-K","ticker":"MGX","cik":"0001785279","company_name":"Metagenomi Therapeutics, Inc.","filed_at":"2025-05-14T23:59:59+00:00","discovered_at":"2026-05-14T18:02:49.712864+00:00","generated_at":"2026-05-21T09:33:34.239849+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Metagenomi presents in vivo CNS gene editing data at ASGCT; CAST integration efficiency improved >50x","bullets":["Type II nuclease MG21-1 in single AAV achieved 69% protein knockdown in mouse motor cortex and 82% in brain via systemic delivery.","Ultra-compact Type V nuclease MG119-28 (488 aa) achieved 64% target protein knockdown and up to 52% editing efficiency in mouse CNS.","Type V-K CAST system engineered for >50x improvement in large gene integration efficiency vs. natural system in mammalian cells.","In vitro, MG119-28 restored dystrophin levels >50% in DMD myocytes and achieved complete gene disruption in K562 cells.","Platform aims to enable extrahepatic in vivo gene editing for neurological and neuromuscular disorders."],"urls":{"canonical":"https://secwatch.observer/filing/0000950170-25-070906","json":"https://secwatch.observer/filing/0000950170-25-070906.json","markdown":"https://secwatch.observer/filing/0000950170-25-070906.md","text":"https://secwatch.observer/filing/0000950170-25-070906.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1785279/000095017025070906/0000950170-25-070906-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1785279/000095017025070906/mgx-20250514.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-21T09:33:34.239849+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}