Sana reports positive six-month data for islet cell therapy in type 1 diabetes without immunosuppression

Sana Biotechnology, Inc.

Six-month results: transplanted allogeneic islet cells (UP421) safe, survive, evade immune system, produce insulin without immunosuppression.
C-peptide detectable fasting and increases with mixed meal tolerance test, confirming insulin secretion; MRI shows graft survival at 6 months.
No safety issues; HIP-modified cells evade both allogeneic and autoimmune responses in type 1 diabetes patient.
Sana plans to file IND for SC451 (stem cell-derived HIP islet therapy) as soon as next year, incorporating UP421 learnings.
Data presented at ADA 85th Scientific Sessions; study funded by Helmsley Charitable Trust, partnership with Uppsala University Hospital.

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