---
schema_version: "secwatch.filing_event.v1"
accession: "0001104659-21-136957"
form_type: "8-K"
ticker: "HYPD"
cik: "0001682639"
company_name: "HYPERION DEFI, INC."
filed_at: "2021-11-10T23:59:59+00:00"
generated_at: "2026-06-28T10:01:52.176830+00:00"
event_type: "earnings"
sentiment: "neutral"
materiality_score: 0.65
calibrated_materiality_score: 0.65
confidence: "high"
source: SEC EDGAR
---

# Eyenovia reports Q3 net loss $5.6M; Chairman Eshelman to step down

## Summary
- Net loss of $5.6M ($0.21 per share) vs $5.1M ($0.23) in Q3 2020; R&D $3.5M, G&A $2.4M.
- Cash $21.4M at Sept 30; expects to fund MydCombi resubmission, MicroLine Phase 3, and manufacturing.
- First patient enrolled in VISION-2 Phase 3 presbyopia trial; topline data expected mid-2022.
- FDA issued Complete Response Letter reclassifying MydCombi as drug-device combo; expedited resubmission planned early 2022.
- Chairman Fred Eshelman to resign by end of 2021; not due to disagreement; Board search to follow.

## SEC filing metadata
- accession: 0001104659-21-136957
- form_type: 8-K
- ticker: HYPD
- cik: 0001682639
- company_name: HYPERION DEFI, INC.
- filed_at: 2021-11-10T23:59:59+00:00
- event_type: earnings
- sentiment: neutral
- materiality_score: 0.65
- calibrated_materiality_score: 0.65
- confidence: high
- sec_items: 2.02, 5.02, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1682639/000110465921136957/0001104659-21-136957-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1682639/000110465921136957/tm2132498d1_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001104659-21-136957
- JSON: https://secwatch.observer/filing/0001104659-21-136957.json
- Plain text: https://secwatch.observer/filing/0001104659-21-136957.txt

## Key facts
- Executive change
  Fred Eshelman resigned as Chairman of the Eyenovia Board at HYPERION DEFI, INC..
  - Action: resigned
  - Role: Chairman of the Eyenovia Board
  source text: Dr. Fred Eshelman, who has served as Chairman of the Eyenovia Board since 2014, will step down from the Board by the end of 2021 to pursue other professional interests.
  evidence_url: https://www.sec.gov/Archives/edgar/data/1682639/000110465921136957/0001104659-21-136957-index.htm

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.