{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-21-139169","form_type":"8-K","ticker":"NXTC","cik":"0001661059","company_name":"NextCure, Inc.","filed_at":"2021-11-15T23:59:59+00:00","discovered_at":"2026-05-14T18:04:13.547447+00:00","generated_at":"2026-06-28T08:27:18.936938+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"NextCure reports NC318 37% DCR, 5.0 mo median PFS; NC410 safe in Ph1","bullets":["NC318 Phase 1/2: 37% disease control rate, median PFS 5.0 mo across all tumors; lung cohort 45% DCR, median PFS 5.2 mo.","Two NSCLC patients on NC318 >2 years: one CR at 2.8 years, one PR at 2.2 years.","Modeling predicts 800 mg weekly NC318 yields ~10x exposure; sS15 may be biomarker for patient selection.","NC410 Ph1 (n=19) up to 60 mg Q2W: no dose-limiting toxicities; shows target binding, immune modulation, ECM remodeling.","Non-clinical data: NC410 synergizes with bintrafusp alpha (TGF-β trap) for tumor control in colon cancer model."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-21-139169","json":"https://secwatch.observer/filing/0001104659-21-139169.json","markdown":"https://secwatch.observer/filing/0001104659-21-139169.md","text":"https://secwatch.observer/filing/0001104659-21-139169.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1661059/000110465921139169/0001104659-21-139169-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1661059/000110465921139169/tm2132890d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-28T08:27:18.936938+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}