{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-22-002406","form_type":"8-K","ticker":"HEPA","cik":"0001583771","company_name":"Hepion Pharmaceuticals, Inc.","filed_at":"2022-01-10T23:59:59+00:00","discovered_at":"2026-05-14T18:04:07.201846+00:00","generated_at":"2026-06-27T19:25:27.766085+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Hepion provides pipeline update: Rencofilstat Phase 2a NASH trial positive; Phase 2b and HCC trials underway","bullets":["Phase 2a NASH trial (AMBITION) met safety endpoints; showed ALT and Pro-C3 reductions over 28 days.","Cash $98.7M as of Sept 30, 2021; 76.2M shares outstanding.","Phase 2b NASH trial (ASCEND-NASH) to randomize 336 subjects across 75, 150, 225 mg doses for 12 months.","Phase 2a HCC trial (HEPA-RENCOFILSTAT-209) launched with Simon 2-stage design; primary endpoint disease control rate.","AI-POWR platform predicts responders; transcriptomics misclassification error <5% in Phase 2a analysis."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-22-002406","json":"https://secwatch.observer/filing/0001104659-22-002406.json","markdown":"https://secwatch.observer/filing/0001104659-22-002406.md","text":"https://secwatch.observer/filing/0001104659-22-002406.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1583771/000110465922002406/0001104659-22-002406-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1583771/000110465922002406/tm222379d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-27T19:25:27.766085+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}