{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-23-037397","form_type":"8-K","ticker":"CGTX","cik":"0001455365","company_name":"COGNITION THERAPEUTICS INC","filed_at":"2023-03-28T23:59:59+00:00","discovered_at":"2026-05-14T18:03:45.077337+00:00","generated_at":"2026-06-17T12:35:44.323085+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"high","headline":"Cognition Therapeutics reports CT1812 alters Alzheimer's disease biomarkers in meta-analysis of 24 patients","bullets":["Meta-analysis of 24 participants (SHINE-A) and full SPARC dataset showed CT1812 significantly alters 28 biomarkers.","11 of 28 biomarkers are priority Alzheimer's targets; effects seen on clusterin (CLU) and prion protein (PRPN).","Pathways affected include synapse health, neuroinflammation, and amyloid-β biology, consistent with mechanism.","Data presented at AD/PD 2023 conference; management says findings strengthen understanding of CT1812's effect on Aβ oligomer-driven neurotoxicity.","Ongoing trials expected to read out in coming months."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-23-037397","json":"https://secwatch.observer/filing/0001104659-23-037397.json","markdown":"https://secwatch.observer/filing/0001104659-23-037397.md","text":"https://secwatch.observer/filing/0001104659-23-037397.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1455365/000110465923037397/0001104659-23-037397-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1455365/000110465923037397/tm2310682d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-17T12:35:44.323085+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}