---
schema_version: "secwatch.filing_event.v1"
accession: "0001104659-23-040523"
form_type: "8-K"
ticker: "BCYC"
cik: "0001761612"
company_name: "BICYCLE THERAPEUTICS PLC"
filed_at: "2023-04-03T23:59:59+00:00"
generated_at: "2026-06-17T07:09:34.701713+00:00"
event_type: "leadership"
sentiment: "positive"
materiality_score: 0.55
calibrated_materiality_score: 0.55
confidence: "high"
source: SEC EDGAR
---

# Bicycle Therapeutics appoints Dr. Arroyo as CDO, promotes Perry to SVP Commercial; CMO leaves

## Summary
- Santiago Arroyo appointed Chief Development Officer effective March 31, 2023; formerly CMO at Momenta and Fulcrum.
- Jennifer Perry promoted to Senior Vice President, Commercial; over 20 years pharma experience in oncology.
- Dominic Smethurst, former Chief Medical Officer, has left the company; CEO thanked him for contributions.
- Arroyo to oversee pipeline expansion and late-stage development; Perry to build commercial organization.
- Company advancing oncology programs BT8009, BT5528, and BT7480 in the clinic.

## SEC filing metadata
- accession: 0001104659-23-040523
- form_type: 8-K
- ticker: BCYC
- cik: 0001761612
- company_name: BICYCLE THERAPEUTICS PLC
- filed_at: 2023-04-03T23:59:59+00:00
- event_type: leadership
- sentiment: positive
- materiality_score: 0.55
- calibrated_materiality_score: 0.55
- confidence: high
- sec_items: 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1761612/000110465923040523/0001104659-23-040523-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1761612/000110465923040523/tm2311247d1_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001104659-23-040523
- JSON: https://secwatch.observer/filing/0001104659-23-040523.json
- Plain text: https://secwatch.observer/filing/0001104659-23-040523.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.