{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-044909","form_type":"8-K","ticker":"IPSC","cik":"0001850119","company_name":"Century Therapeutics, Inc.","filed_at":"2024-04-09T23:59:59+00:00","discovered_at":"2026-05-14T18:03:20.815308+00:00","generated_at":"2026-06-04T01:07:06.051379+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"Century Therapeutics presents novel iPSC-derived cell therapy preclinical data at AACR 2024","bullets":["CD19xCD22 bispecific CAR showed cytotoxicity against CD19/CD22 tumor cells in vitro and in xenograft models.","Allo-Evasion platform: combining HLA-E and HLA-G offered best protection against NK-mediated rejection of iPSC-derived cells.","NECTIN4-targeted iPSC-derived CAR-T demonstrated tumor inhibition comparable to Enfortumab-based CAR in OVCar-3 xenografts.","CXCR4 transgene in iPSC-derived NK cells enhanced migration and anti-tumor efficacy in vivo, eliminating bone disease.","Novel inhibitory CAR targeting DSG1 designed to reduce off-tumor skin toxicity of NECTIN4 therapy."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-044909","json":"https://secwatch.observer/filing/0001104659-24-044909.json","markdown":"https://secwatch.observer/filing/0001104659-24-044909.md","text":"https://secwatch.observer/filing/0001104659-24-044909.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1850119/000110465924044909/0001104659-24-044909-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1850119/000110465924044909/tm2411338d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-04T01:07:06.051379+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}