{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-063829","form_type":"8-K","ticker":"ANVS","cik":"0001477845","company_name":"Annovis Bio, Inc.","filed_at":"2024-05-21T23:59:59+00:00","discovered_at":"2026-05-14T18:03:18.592413+00:00","generated_at":"2026-06-01T10:42:56.367933+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"neutral","materiality_score":0.35,"calibrated_materiality_score":0.35,"confidence":"high","headline":"Annovis Bio publishes Posiphen PK comparison across species in Biomolecules","bullets":["Publication in Biomolecules compares Posiphen pharmacokinetics across mouse, rat, dog, and human samples.","Posiphen reaches peak plasma concentration quickly, with high brain and CSF absorption.","Drug metabolizes into N1-norposiphen and N8-norposiphen; rapid clearance in plasma but longer retention in brain/CSF.","Absorption, distribution, metabolism, and excretion similar in healthy volunteers and Alzheimer's/Parkinson's patients.","CEO Maria Maccecchini states publication consolidates years of research for a holistic view of Posiphen."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-063829","json":"https://secwatch.observer/filing/0001104659-24-063829.json","markdown":"https://secwatch.observer/filing/0001104659-24-063829.md","text":"https://secwatch.observer/filing/0001104659-24-063829.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924063829/0001104659-24-063829-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924063829/tm2415055d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T10:42:56.367933+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}