{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-074956","form_type":"8-K","ticker":"VSTM","cik":"0001526119","company_name":"Verastem, Inc.","filed_at":"2024-06-26T23:59:59+00:00","discovered_at":"2026-05-14T18:03:18.831218+00:00","generated_at":"2026-06-01T01:29:01.105082+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Verastem initiates rolling NDA for avutometinib+defactinib in recurrent LGSOC; ORR 27%","bullets":["Rolling NDA submission for avutometinib + defactinib in recurrent LGSOC started H2 2024; potential FDA approval in 2025.","RAMP 201 trial (Feb 2024 cutoff): ORR 27% overall (95% CI 19%-36%), 37% KRAS mt, 15% KRAS wt.","Clinical benefit rate (CR+PR+SD≥6 months) 60%; discontinuation due to AEs only 9%.","No FDA-approved treatments for LGSOC; SoC studies show ORR 6-13% with 17-30% discontinuation.","Market opportunity: $1.7B+ prevalent KRAS mt addressable; 70% of oncologists surveyed would adopt within 6 months of approval."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-074956","json":"https://secwatch.observer/filing/0001104659-24-074956.json","markdown":"https://secwatch.observer/filing/0001104659-24-074956.md","text":"https://secwatch.observer/filing/0001104659-24-074956.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1526119/000110465924074956/0001104659-24-074956-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1526119/000110465924074956/tm2418267d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-06-01T01:29:01.105082+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}