{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-077093","form_type":"8-K","ticker":"ANVS","cik":"0001477845","company_name":"Annovis Bio, Inc.","filed_at":"2024-07-02T23:59:59+00:00","discovered_at":"2026-05-14T18:03:13.196814+00:00","generated_at":"2026-05-31T23:45:16.148343+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Buntanetap shows dose-dependent cognition gains; MDS-UPDRS improvements in PD Phase III","bullets":["Buntanetap at 20mg significantly improved MDS-UPDRS Part II, III, II+III, and Total in PD patients diagnosed >3 years.","In patients with mild dementia (MMSE 20-26), 20mg buntanetap showed significant cognitive improvement vs placebo.","PIGD subgroup also showed significant motor and non-motor improvements with buntanetap.","Safety profile consistent with prior AD data; no significant differences between early/advanced PD.","FDA feedback led to primary endpoint change; primary and secondary endpoints met in specified subgroups."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-077093","json":"https://secwatch.observer/filing/0001104659-24-077093.json","markdown":"https://secwatch.observer/filing/0001104659-24-077093.md","text":"https://secwatch.observer/filing/0001104659-24-077093.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924077093/0001104659-24-077093-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924077093/tm2418712d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T23:45:16.148343+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}