{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-081882","form_type":"8-K","ticker":"VSTM","cik":"0001526119","company_name":"Verastem, Inc.","filed_at":"2024-07-23T23:59:59+00:00","discovered_at":"2026-05-14T18:03:13.374119+00:00","generated_at":"2026-05-31T18:01:55.130557+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.55,"calibrated_materiality_score":0.55,"confidence":"high","headline":"Verastem initiates rolling NDA for avutometinib/defactinib; RAMP 201 median duration 9 months","bullets":["Rolling NDA for avutometinib+defactinib in recurrent KRAS mutant LGSOC started May 2024; priority review requested.","RAMP 201 interim data (Feb 2024 cutoff): median duration 9 months; KRAS mt 14 months, KRAS wt 7 months; 31/58 KRAS mt still on treatment.","Estimated addressable market: annual ~$300M KRAS mt, ~$270M KRAS wt; prevalent ~$1.7B KRAS mt, ~$1.1B KRAS wt based on $34k/month cost.","GenFleet collaboration: IND cleared June 2024, first patient dosed in China Phase 1/2 for KRAS G12D inhibitor GFH375/VS-7375."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-081882","json":"https://secwatch.observer/filing/0001104659-24-081882.json","markdown":"https://secwatch.observer/filing/0001104659-24-081882.md","text":"https://secwatch.observer/filing/0001104659-24-081882.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1526119/000110465924081882/0001104659-24-081882-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1526119/000110465924081882/tm2413643d3_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T18:01:55.130557+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}