{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-086114","form_type":"8-K","ticker":"ANVS","cik":"0001477845","company_name":"Annovis Bio, Inc.","filed_at":"2024-08-06T23:59:59+00:00","discovered_at":"2026-05-14T18:03:13.197654+00:00","generated_at":"2026-05-31T12:13:58.919184+00:00","sec_items":["7.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Annovis Bio: buntanetap + GLP-1 agonist shows synergistic cognitive boost in AD mouse model","bullets":["Combination of buntanetap and dulaglutide (Trulicity) restored cognitive function beyond healthy controls in Alzheimer's mouse model.","Buntanetap alone restored to 100%, dulaglutide alone to 80%; combination showed 6-10x increase in efficacy.","GLP-1 agonist dulaglutide was chosen for its good blood-brain barrier permeability among single-chain peptides.","CEO Maria Maccecchini noted synergy could enhance treatment outcomes while minimizing side effects."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-086114","json":"https://secwatch.observer/filing/0001104659-24-086114.json","markdown":"https://secwatch.observer/filing/0001104659-24-086114.md","text":"https://secwatch.observer/filing/0001104659-24-086114.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924086114/0001104659-24-086114-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1477845/000110465924086114/tm2420928d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-31T12:13:58.919184+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}