{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-107052","form_type":"8-K","ticker":"GANX","cik":"0001819411","company_name":"Gain Therapeutics, Inc.","filed_at":"2024-10-08T23:59:59+00:00","discovered_at":"2026-05-14T18:03:09.815544+00:00","generated_at":"2026-05-30T18:13:31.655272+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Gain Therapeutics reports preclinical GT-02287 data showing disease-modifying potential in Parkinson's models","bullets":["GT-02287 rescued motor and cognitive deficits in GBA1 and idiopathic PD models; effects persisted >1 week after drug withdrawal.","GT-02287 improved mitochondrial function and reduced α-synuclein aggregation in GBA1-PD in vitro and in vivo models.","GT-02287 reduced Tau accumulation in GBA1-mutant and wild-type cell lines, suggesting potential for Alzheimer's disease.","Delayed GT-02287 administration restored motor function to control levels and reduced neurodegeneration markers (NfL)."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-107052","json":"https://secwatch.observer/filing/0001104659-24-107052.json","markdown":"https://secwatch.observer/filing/0001104659-24-107052.md","text":"https://secwatch.observer/filing/0001104659-24-107052.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1819411/000110465924107052/0001104659-24-107052-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1819411/000110465924107052/tm2425756d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-30T18:13:31.655272+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}