{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-24-119760","form_type":"8-K","ticker":"HYPD","cik":"0001682639","company_name":"HYPERION DEFI, INC.","filed_at":"2024-11-15T23:59:59+00:00","discovered_at":"2026-05-14T18:03:09.217278+00:00","generated_at":"2026-05-29T23:49:32.826733+00:00","sec_items":["2.05","8.01","9.01"],"event_type":"other_material","sentiment":"negative","materiality_score":0.9,"calibrated_materiality_score":0.9,"confidence":"high","headline":"Eyenovia Phase 3 CHAPERONE myopia trial fails; cuts 50% staff, explores strategic options","bullets":["Independent DRC found CHAPERONE not meeting primary endpoint of <0.5 diopter progression over 3 years; study terminated.","252 evaluable patients; no significant difference between active arms (0.01% and 0.1% atropine) and placebo.","Workforce reduction of ~50% with $0.2M severance; remaining staff focused on Optejet Gen-2, dry eye collaborations, clobetasol.","Company evaluating strategic options: business combination, reverse merger, or asset sales.","Safety profile acceptable; mild and infrequent adverse events across all doses."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-24-119760","json":"https://secwatch.observer/filing/0001104659-24-119760.json","markdown":"https://secwatch.observer/filing/0001104659-24-119760.md","text":"https://secwatch.observer/filing/0001104659-24-119760.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1682639/000110465924119760/0001104659-24-119760-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1682639/000110465924119760/tm2428238d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-29T23:49:32.826733+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}