other material
confidence high
sentiment negative
materiality 0.85
Passage Bio cuts workforce 55%, extends cash runway into Q1 2027; updates PBFT02 data
Passage BIO, Inc.
- Preliminary cash $76.8M as of Dec 31, 2024; expected runway into Q1 2027 after restructuring.
- Workforce reduced ~55%; lab operations in Hopewell, NJ ceased; annual cost savings $9-11M; severance $2M.
- Expects $1-3M impairment on lab equipment in Q1 2025; non-cash, no impact on cash runway.
- PBFT02 (FTD-GRN) interim data: CSF PGRN increased from <3 to 13-27 ng/mL at 6 months (n=4), durable to 18 months.
- Plasma NfL decreased 13% vs baseline at 12 months (n=2); vs 29% annual increase in untreated per literature.