{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-25-043014","form_type":"8-K","ticker":"BCYC","cik":"0001761612","company_name":"BICYCLE THERAPEUTICS PLC","filed_at":"2025-05-01T23:59:59+00:00","discovered_at":"2026-05-14T18:02:49.623656+00:00","generated_at":"2026-05-23T00:50:30.111533+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Bicycle Therapeutics Q1 net loss $60.8M; cash $793M; Duravelo-3 trial recruiting","bullets":["Net loss of $60.8M ($0.88 per share) vs $26.6M ($0.62) in Q1 2024; R&D expense $59.1M (+69% YoY).","Cash and equivalents $793.0M as of March 31, 2025, down from $879.5M at Dec 31, 2024; runway into 2H 2027.","Phase 1/2 Duravelo-3 trial for zelenectide pevedotin in NECTIN4-amplified breast cancer open and recruiting.","Felix J. Baker to succeed Pierre Legault as Board chairman; Legault and Richard Kender retiring at June 17 AGM.","2 abstracts accepted for 2025 ASCO; dose selection for Duravelo-2 in mUC on track for 2H 2025."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-25-043014","json":"https://secwatch.observer/filing/0001104659-25-043014.json","markdown":"https://secwatch.observer/filing/0001104659-25-043014.md","text":"https://secwatch.observer/filing/0001104659-25-043014.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1761612/000110465925043014/0001104659-25-043014-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1761612/000110465925043014/tm2513585d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-23T00:50:30.111533+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}