Verastem reports 83% ORR for avutometinib+defactinib in front-line metastatic PDAC

Verastem, Inc.

Dose level 1 (RP2D) achieved 83% ORR (10/12 partial responses) in RAMP 205 trial of frontline metastatic pancreatic cancer.
Across all 5 dose cohorts, 92% (48/52) of evaluable patients showed tumor reduction.
Company plans to start registrational Phase 3 trial in front-line metastatic PDAC in 2026.
No new safety signals; adverse events consistent with previously reported profile.
R&D webcast on June 2, 2025 to discuss RAMP 205 data and VS-7375 KRAS G12D inhibitor data.

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