VYNE Phase 2b Repibresib vitiligo trial misses F-VASI50, terminates extension, seeks partner

VYNE Therapeutics Inc.

Primary endpoint F-VASI50 at Week 24 not met: 19.5% for 3% vs 23.4% vehicle (p=0.1245).
Key secondary endpoint F-VASI75 also not met (9.8% vs 6.4%, p=0.1468).
Nominal statistical significance for 3% dose on percent CFB in F-VASI (-43.6% vs -25.6%, p=0.002) and T-VASI (-28.3% vs -16.2%, p=0.044).
High vehicle effect and dropout rate in active arms (36.6% for 3% vs 10.6% vehicle); company ends trial extension phase.
Preliminary cash $39.6M as of June 30, 2025; company seeking partner for Repibresib.

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