{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-25-072708","form_type":"8-K","ticker":"SNGX","cik":"0000812796","company_name":"SOLIGENIX, INC.","filed_at":"2025-07-31T23:59:59+00:00","discovered_at":"2026-05-14T18:02:46.429878+00:00","generated_at":"2026-05-17T22:35:21.454662+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.7,"calibrated_materiality_score":0.7,"confidence":"high","headline":"Soligenix SGX945 Phase 2a: 40% improvement in Behçet's ulcers, matching Otezla's 37%","bullets":["SGX945 achieved 40% improvement vs placebo on primary endpoint at Week 4; apremilast (Otezla) had 37% improvement.","7 of 8 patients reported benefit; 1 patient's skin ulcer resolved; no treatment-related adverse events.","Improvement sustained at Week 8 (32%) despite stopping treatment at Week 4; Otezla continuous dosing had 41%.","Company plans reformulation for home subcutaneous injection and a placebo-controlled Phase 2 study.","Behçet's Disease affects ~18,000 in US; SGX945 well-tolerated with no GI side effects vs Otezla."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-25-072708","json":"https://secwatch.observer/filing/0001104659-25-072708.json","markdown":"https://secwatch.observer/filing/0001104659-25-072708.md","text":"https://secwatch.observer/filing/0001104659-25-072708.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/812796/000110465925072708/0001104659-25-072708-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/812796/000110465925072708/tm2522246d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T22:35:21.454662+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}