{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-25-097739","form_type":"8-K","ticker":"TOVX","cik":"0000894158","company_name":"Theriva Biologics, Inc.","filed_at":"2025-10-08T23:59:59+00:00","discovered_at":"2026-05-14T18:02:42.517187+00:00","generated_at":"2026-05-17T04:23:09.469137+00:00","sec_items":["8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.5,"calibrated_materiality_score":0.5,"confidence":"high","headline":"Theriva Biologics unveils positive preclinical data for VCN-12, showing superiority over VCN-01","bullets":["VCN-12 showed up to 13.7x greater cytotoxicity than VCN-01 across multiple cancer cell lines in vitro.","In HP-1 pancreatic tumor hamster model, VCN-12 significantly reduced growth in both injected and non-injected tumors.","Complete tumor regression in 2/9 hamsters; those animals rejected tumor re-challenge 43 days later.","VCN-12 incorporates bee hyaluronidase (higher activity) and parasporin-2 to enhance immunogenic cell death.","Toxicity profile in mice similar to VCN-01; further preclinical studies planned."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-25-097739","json":"https://secwatch.observer/filing/0001104659-25-097739.json","markdown":"https://secwatch.observer/filing/0001104659-25-097739.md","text":"https://secwatch.observer/filing/0001104659-25-097739.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/894158/000110465925097739/0001104659-25-097739-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/894158/000110465925097739/tm2528131d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T04:23:09.469137+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}