{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-25-100646","form_type":"8-K","ticker":"CYPH","cik":"0001509745","company_name":"CYPHERPUNK TECHNOLOGIES INC.","filed_at":"2025-10-20T23:59:59+00:00","discovered_at":"2026-05-14T18:02:39.591498+00:00","generated_at":"2026-05-17T03:13:11.623116+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.75,"calibrated_materiality_score":0.75,"confidence":"high","headline":"Leap's sirexatamab shows statistically significant PFS/OS benefit in DKK1-high CRC at ESMO 2025","bullets":["In DKK1-high (upper median, n=88): mPFS 9.03 vs 7.06 mo (HR 0.61, p=0.0255); mOS not reached vs 14.39 mo (HR 0.42, p=0.0118).","In DKK1-high (upper quartile, n=44): mPFS 9.36 vs 5.88 mo (HR 0.46, p=0.017); mOS not reached vs 9.66 mo (HR 0.17, p<0.001).","Full ITT (n=188): mPFS 9.2 vs 8.3 mo (HR 0.84, p=0.171); ORR 35.1% vs 26.6%.","Sirexatamab well tolerated; TEAE profile similar between arms.","Leap plans to engage regulators on registrational path for sirexatamab in CRC; supported by recent financing."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-25-100646","json":"https://secwatch.observer/filing/0001104659-25-100646.json","markdown":"https://secwatch.observer/filing/0001104659-25-100646.md","text":"https://secwatch.observer/filing/0001104659-25-100646.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1509745/000110465925100646/0001104659-25-100646-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1509745/000110465925100646/tm2529085d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T03:13:11.623116+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}