{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-25-104004","form_type":"8-K","ticker":"BCYC","cik":"0001761612","company_name":"BICYCLE THERAPEUTICS PLC","filed_at":"2025-10-30T23:59:59+00:00","discovered_at":"2026-05-14T18:02:40.361379+00:00","generated_at":"2026-05-17T01:23:36.365110+00:00","sec_items":["2.02","9.01"],"event_type":"earnings","sentiment":"neutral","materiality_score":0.6,"calibrated_materiality_score":0.6,"confidence":"high","headline":"Bicycle Therapeutics Q3 net loss $59.1M; lead drug regulatory update delayed to Q1 2026","bullets":["Net loss of $59.1M ($0.85 per share) vs $50.8M ($0.74) in Q3 2024; R&D expenses up 21% to $58.4M.","Cash $648.3M (down from $879.5M at Dec 2024); additional $38.2M R&D tax credit received Oct 2025; runway into 2028.","Dose selection for zelenectide pevedotin Duravelo-2 trial and potential approval pathway update expected Q1 2026.","Strengthened Board with appointments of Charles Swanton, Roger Dansey, and Hervé Hoppenot.","BT5528 and BT7480 combination data presentations pushed to H1 2026; initial BRC EphA2 human imaging data expected H1 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-25-104004","json":"https://secwatch.observer/filing/0001104659-25-104004.json","markdown":"https://secwatch.observer/filing/0001104659-25-104004.md","text":"https://secwatch.observer/filing/0001104659-25-104004.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1761612/000110465925104004/0001104659-25-104004-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1761612/000110465925104004/tm2529754d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-17T01:23:36.365110+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}