{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-26-065908","form_type":"8-K","ticker":"EDIT","cik":"0001650664","company_name":"Editas Medicine, Inc.","filed_at":"2026-05-26T10:09:56+00:00","discovered_at":"2026-05-26T10:15:00.294231+00:00","generated_at":"2026-05-26T10:16:37.515883+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"confidence":"high","headline":"EDIT-401 preclinical data shows ~90% mean reductions in LDL-C, Lp(a), ApoB in NHPs","bullets":["Single dose achieved ≥90% mean reduction in LDL-C, rapid and dose-dependent, durable through 6 months in NHPs.","Achieved ~90% mean reduction in Lp(a) and ApoB, supporting unified LDLR upregulation mechanism.","Well-tolerated at therapeutically relevant dose 1.5 mg/kg; no adverse observations in ongoing GLP toxicology.","Plans to submit CTN in Australia by mid-2026; first-in-human HeFH trial later in 2026; early human PoC data by end of 2026.","Received positive pre-IND feedback from FDA on nonclinical package, CMC plans, and study design."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-26-065908","json":"https://secwatch.observer/filing/0001104659-26-065908.json","markdown":"https://secwatch.observer/filing/0001104659-26-065908.md","text":"https://secwatch.observer/filing/0001104659-26-065908.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1650664/000110465926065908/0001104659-26-065908-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1650664/000110465926065908/tm2615565d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-05-26T10:16:37.515883+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}