NextCure Phase 1 SIM0505 data: 55% ORR in gynecologic cancers; cash into Q1 2027

NextCure, Inc.

ORR of 55% (11/20) in gynecologic cancers at 4.8-8.0 mg/kg with ≥12 wks follow-up; 52.9% in ovarian, 66.7% in USC.
TEAEs leading to dose discontinuation in 3 patients (Gr2 ILD, Gr3 fungal pneumonia, Gr4 thrombocytopenia); no primary prophylaxis for hematologic toxicities used.
Patients heavily pretreated: median 5 prior systemic regimens (range 1-12); 78% ovarian cancer.
Cash, cash equivalents and marketable securities expected to fund operations into Q1 2027.
Virtual KOL event scheduled for June 2, 2026 at 8 AM ET.

item 7.01 item 8.01 item 9.01

Machine-readable event card

schema_version: secwatch.filing_event.v1
accession: 0001104659-26-068604
form_type: 8-K
ticker: NXTC
cik: 0001661059
company_name: NextCure, Inc.
filed_at: 2026-06-01T12:10:58+00:00
discovered_at: 2026-06-01T12:15:00.320830+00:00
generated_at: 2026-06-01T12:15:27.372596+00:00
sec_items: ["7.01", "8.01", "9.01"]
event_type: other_material
sentiment: positive
materiality_score: 0.75
calibrated_materiality_score: 0.75
confidence: high
secwatch_canonical_url: https://secwatch.observer/filing/0001104659-26-068604
json_url: https://secwatch.observer/filing/0001104659-26-068604.json
markdown_url: https://secwatch.observer/filing/0001104659-26-068604.md
text_url: https://secwatch.observer/filing/0001104659-26-068604.txt
edgar_index_url: https://www.sec.gov/Archives/edgar/data/1661059/000110465926068604/0001104659-26-068604-index.htm
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