{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-26-082906","form_type":"8-K","ticker":"VYGR","cik":"0001640266","company_name":"Voyager Therapeutics, Inc.","filed_at":"2026-07-13T12:44:19+00:00","discovered_at":"2026-07-13T12:45:00.262421+00:00","generated_at":"2026-07-13T12:45:04.197326+00:00","sec_items":["8.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.65,"calibrated_materiality_score":0.65,"confidence":"high","headline":"Voyager presents positive GLP tox data for tau gene therapy VY1706; plans H2 2026 dosing","bullets":["GLP toxicology data for VY1706 showed favorable tolerability in NHPs with no adverse CNS or peripheral findings up to 5x10^13 vg/kg.","Single IV dose achieved up to 75% lowering of MAPT mRNA and tau protein in key AD brain regions through six months.","ALPL brain vasculature receptor mediated VY1706 blood-brain barrier transport, supporting cross-species translatability.","IND clearance received June 2026; multi-site open-label dose-escalation trial to begin dosing in H2 2026.","Data presented at Alzheimer's Association International Conference on July 13, 2026."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-26-082906","json":"https://secwatch.observer/filing/0001104659-26-082906.json","markdown":"https://secwatch.observer/filing/0001104659-26-082906.md","text":"https://secwatch.observer/filing/0001104659-26-082906.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1640266/000110465926082906/0001104659-26-082906-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1640266/000110465926082906/tm2620191d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-07-13T12:45:04.197326+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}