{"schema_version":"secwatch.filing_event.v1","accession":"0001104659-26-094528","form_type":"8-K","ticker":"DFTX","cik":"0001813814","company_name":"Definium Therapeutics, Inc.","filed_at":"2026-08-12T12:05:37+00:00","discovered_at":"2026-08-12T12:10:13.324108+00:00","generated_at":"2026-08-12T12:10:26.338989+00:00","sec_items":["7.01","8.01","9.01"],"event_type":"other_material","sentiment":"positive","materiality_score":0.85,"calibrated_materiality_score":0.85,"confidence":"high","headline":"Definium DT120 ODT Phase 3 Voyage study hits primary endpoint in GAD; HAM-A diff -5.4","bullets":["Primary endpoint met: HAM-A LS mean change -11.6 vs placebo -6.2, placebo-adjusted -5.4 (p<0.0001, d=0.81).","Key secondary endpoints met: CGI-S at Week 12 -0.6 (p<0.0001); HAM-A at Week 1 -7.7 (p<0.0001).","HAM-A response rate (≥50%) 43% vs 16% (p<0.0001); remission rate (≤7) 14% vs 4% (p=0.0222).","Safety: mild-to-moderate transient AEs, no new signals, no suicidality; mean EoSC time 6.4 hours.","Panorama GAD topline results expected in September 2026; follows positive Emerge MDD readout in June."],"urls":{"canonical":"https://secwatch.observer/filing/0001104659-26-094528","json":"https://secwatch.observer/filing/0001104659-26-094528.json","markdown":"https://secwatch.observer/filing/0001104659-26-094528.md","text":"https://secwatch.observer/filing/0001104659-26-094528.txt","edgar_index":"https://www.sec.gov/Archives/edgar/data/1813814/000110465926094528/0001104659-26-094528-index.htm","edgar_primary_document":"https://www.sec.gov/Archives/edgar/data/1813814/000110465926094528/tm2622948d1_8k.htm"},"model":{"generated_by":"deepseek-v4-flash:cloud@v2","generated_at":"2026-08-12T12:10:26.338989+00:00"},"review":{"review_status":"machine_generated","human_reviewed":false,"corrected":false,"correction_note":null,"correction_timestamp":null,"superseded_by":null,"related_filings":[]},"source_grounded_claims":[],"license":"Source filings: public domain (SEC EDGAR). Summaries (headline + bullets): CC-BY-4.0; attribute https://secwatch.observer"}