---
schema_version: "secwatch.filing_event.v1"
accession: "0001104659-26-117080"
form_type: "8-K"
ticker: "QNRX"
cik: "0001671502"
company_name: "Quoin Pharmaceuticals, Ltd."
filed_at: "2026-10-20T10:35:29+00:00"
generated_at: "2026-10-20T10:40:06.282361+00:00"
event_type: "other_material"
sentiment: "positive"
materiality_score: 0.45
calibrated_materiality_score: 0.45
confidence: "high"
source: SEC EDGAR
---

# Quoin publishes peer-reviewed QRX003 paper; pediatric Netherton case clear at 21 months

## Summary
- Peer-reviewed paper in Dermatology and Therapy, published online Oct 13, 2026, introduces QRX003 and reports Prof. Alan Irvine's pediatric compassionate-use case.
- Pediatric Netherton patient on once-daily whole-body QRX003 improved IGA from 4 (severe) to 1 at six weeks and WI-NRS itch from 5 to 1.
- By eight months IGA was 0 (clear) and WI-NRS 0; over 21 months mostly IGA 0, off antihistamines, glucocorticoids and antivirals, no treatment-related adverse events.
- Phase 2/3 CL-QRX003-004 interim: 4 of 6 (66.7%) met primary IGA endpoint (p=0.0087 vs alpha 0.0215); full 20-patient enrollment targeted by end-2026, topline Q2 2027.
- Case is first pediatric use of QRX003 and longest continuous exposure to date; authors caution single-patient observations require trial confirmation.

## SEC filing metadata
- accession: 0001104659-26-117080
- form_type: 8-K
- ticker: QNRX
- cik: 0001671502
- company_name: Quoin Pharmaceuticals, Ltd.
- filed_at: 2026-10-20T10:35:29+00:00
- event_type: other_material
- sentiment: positive
- materiality_score: 0.45
- calibrated_materiality_score: 0.45
- confidence: high
- sec_items: 7.01, 8.01, 9.01
- EDGAR index: https://www.sec.gov/Archives/edgar/data/1671502/000110465926117080/0001104659-26-117080-index.htm
- EDGAR primary document: https://www.sec.gov/Archives/edgar/data/1671502/000110465926117080/tm2627720d1_8k.htm

## Machine-readable alternates
- HTML: https://secwatch.observer/filing/0001104659-26-117080
- JSON: https://secwatch.observer/filing/0001104659-26-117080.json
- Plain text: https://secwatch.observer/filing/0001104659-26-117080.txt

This AI-assisted summary is a reading aid. Review the linked SEC EDGAR filing before relying on any specific claim.